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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-526 品牌系列 Upstate
商名 - Upstate
描述 Anti-IRS1 Antibody, pre-CT 产品信息 格式 Purified 控制 - Positive Control Included: 3T3 Cell Lysate (12-305)
演示 Immunoaffinity Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, and 5mg/ml BSA before the addition of glycerol to 30% 应用 应用 Anti-IRS1 Antibody, pre-CT is an antibody against IRS1 for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-linked, precarboxy-terminal 16 residue peptide corresponding to amino acid residues 1220-1235 of rat liver IRS-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes IRS1; does not recognize IRS2. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005544
基因符号 - HIRS-1
- IRS1
- IRS-1
纯化方法 Protein A purfied UniProt编号 - P35568
UniProt汇总 FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
SIZE: 1242 amino acids; 131591 Da
SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.产品使用声明 质量保证 routinely evaluated by immunoblot on a 3T3/A31 RIPA cell lysate or in a L6 RIPA cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,06-744,Anti-DR4/TRAIL-R1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,ACS510024,Amicon Pro Purification System with 100kDa Amicon Ultra-0.5 Device
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