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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-744 品牌系列 Upstate
商名 - Upstate
描述 Anti-DR4/TRAIL-R1 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect DR4/TRAIL-R1 using this Anti-DR4/TRAIL-R1 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide (C-RPAREASPRLRVHK) corresponding to amino acids 77-90 of human DR4/TRAIL-R1 宿主 Rabbit 特异性 DR4/TRAIL-R1 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003844
Entrez基因汇总 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. 基因符号 - Apo2
- TNFRSF10A
- TRAILR1
- APO2
- CD261
- DR4
- TRAIL-R1
- TRAILR-1
- MGC9365
纯化方法 Protein A chromatography UniProt编号 - O00220
UniProt汇总 FUNCTION: SwissProt: O00220 # Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
SIZE: 468 amino acids; 50061 Da
SUBUNIT: Can interact with TRADD and RIP.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
SIMILARITY: SwissProt: O00220 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells, A431, HeLa, HFF, Raji, 3T3, CTLL, L-6 or PC-12 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,AB2269,Anti-Leukocyte immunoglobulin-like receptor 3 Antibody
下一件merck millipore产品：merck millipore,默克密理博,06-526,Anti-IRS1 Antibody, pre-CT
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