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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5781 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Staufen Antibody 背景信息 Staufen homolog 1 binds double-stranded RNA (regardless of the sequence) and tubulin. It may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide. 应用 应用 Anti-Staufen Antibody is an antibody against Staufen for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.5-1.0 μg/mL. Reacts with the ~60 kDa protein in mouse pancreas tissue lysate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from amino acids 458-472 of human Staufen 1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Reacts with Staufen 1. 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_017454.2
- NM_001037328.1
- NM_004602.2
- NM_017452.2
- NM_017453.2
Entrez基因汇总 Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. 基因符号 - staufen
- STAU1
- FLJ25010
- STAU
UniProt编号 - O95793
UniProt汇总 FUNCTION: SwissProt: O95793 # Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
SIZE: 577 amino acids; 63182 Da
SUBUNIT: Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Interacts with the influenza virus nonstructural protein NS1.
SUBCELLULAR LOCATION: Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
TISSUE SPECIFICITY: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
DOMAIN: SwissProt: O95793 One of the DRDB could be involved in RER binding. & The C-terminal contains the tubulin binding domain (TBD) (By similarity).
SIMILARITY: Contains 3 DRBM (double-stranded RNA-binding) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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