merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8

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merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8
产品名称：Anti-Collagen Type VI Antibody, clone F1-8
产品型号：MAB1342
Detect Collagen Type VI using this Anti-Collagen Type VI Antibody, clone F1-8 validated for use in DB, IP, IH.

merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8

产品介绍

merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC	M	Ascites	Monoclonal Antibody

描述
产品目录编号	MAB1342
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Collagen Type VI Antibody, clone F1-8

产品信息
格式	Ascites

应用
应用	Detect Collagen Type VI using this Anti-Collagen Type VI Antibody, clone F1-8 validated for use in DB, IP, IH.
主要应用	Immunohistochemistry
应用说明	Immunohistochemistry: use with cryostat sections fixed with either acetone or 4% formaldehyde. Not tested on paraffin embedded tissues. Immunoprecipitation. Dot-blotting. Final working dilutions must be determined by end user.

生物信息
免疫原品种	SDS-insoluble extracts of human colon tissue.
克隆	F1-8
宿主	Mouse
特异性	Reacts with collagen type VI from human. Specificity established by identical reaction in immunoprecipitation of labeled lysates of human osteosarcoma cells MG63 with a reference monclonal antibody to type VI collagen. MAB1342 precipitates a 140 kDa band and some dimers. The monclonal stains stroma of different organs with a pattern identical to that of the reference antibody.
同种型	IgM
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001845.4
Entrez基因汇总	This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
基因符号	arresten COL4A1 Arresten
UniProt编号	P02462
UniProt汇总	FUNCTION: SwissProt: P02462 # Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells. SIZE: 1669 amino acids; 160615 Da SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)- alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE SPECIFICITY: Highly expressed in placenta. DOMAIN: SwissProt: P02462 Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G- X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. PTM: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates. & Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. & The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues. DISEASE: SwissProt: P02462 # Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant. & Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant. SIMILARITY: Belongs to the type IV collagen family. & Contains 2 COL4C (collagen IV C-terminal) domains.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

包装信息
数量	100 µL

merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8

上一件merck millipore产品：merck millipore,默克密理博,124541,氧化型辅酶II钠盐 ; NADP
下一件merck millipore产品：merck millipore,默克密理博,AB2965,Anti-TIMP-2 (CT) Antibody

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