- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,197331,Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem
产品名称：Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem
产品型号：197331
The Bcl-2 Inhibitor II, YC137, also referenced under CAS 810659-53-1, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
merck millipore,默克密理博,197331,Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₁N₃O₆S₂ 810659-53-1 描述 概述 A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9. 产品目录编号 197331 品牌系列 Calbiochem®
同义词 2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester 参考 参考 Real, P.J., et al. 2004. Cancer Res. 64, 7947. 产品信息 CAS号 810659-53-1 具有ATP竞争性 N 形式 Red solid Hill配方 C₂₄H₂₁N₃O₆S₂ 化学配方 C₂₄H₂₁N₃O₆S₂ Molar Mass 511.6 可逆 N 结构配方图像 生物信息 主靶 Bcl-2 主靶Ki 1.3 µM in binding Bcl-2 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,AB2965,Anti-TIMP-2 (CT) Antibody
下一件merck millipore产品：merck millipore,默克密理博,17-10205,LentiBrite ™ RFP-Tubulin Lentiviral Biosensor
相关产品
merck millipore,默克密理博,AB9870,Anti-STIM1 Antibody
merck millipore,默克密理博,17-10267,ChIPAb+™ FOXA1 Antibody
merck millipore,默克密理博,124541,氧化型辅酶II钠盐 ; NADP
merck millipore,默克密理博,MAB1342,Anti-Collagen Type VI Antibody, clone F1-8
merck millipore,默克密理博,AB2965,Anti-TIMP-2 (CT) Antibody
merck millipore,默克密理博,17-10205,LentiBrite ™ RFP-Tubulin Lentiviral Biosensor
merck millipore,默克密理博,AB5781,Anti-Staufen Antibody
merck millipore,默克密理博,AB5200-200UL,Anti-Potassium Channel GIRK2 Antibody
merck millipore,默克密理博,MAB4303,Anti-Stage-Specific Embryonic Antigen-3 Antibody, clone MC-631
merck millipore,默克密理博,MAB1393,Anti-PECAM-1 Antibody, clone TLD-3A12