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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R, B, Po, Eq, Ca WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2965 Replaces AB19029 描述 Anti-TIMP-2 (CT) Antibody Alternate Names - metalloproteinase inhibitor 2
- TIMP metallopeptidase inhibitor 2
- tissue inhibitor of metalloproteinase 2
- Tissue inhibitor of metalloproteinases 2
背景信息 Tissue inhibitor of metalloproteinases 2 (TIMP-2) is a member of the protease inhibitor I35 (TIMP) family. TIMP-2 binds with the catalytic zinc cofactors of metalloproteinases, thereby forming a complex and irreversibly activating them. High concentrations of TIMP-2 have been shown to down-regulate progelatinase A activation. TIMP-2 performs a regulatory role for cell proliferation. It interacts with several MMPs including MMP-1 to MMP-3, MMP-7 to MMP-10, MMP-13 to MMP-16, MMP-19, and MT1-MMP. MMP-2 activity is inhibited through interaction with TIMP-2. 产品信息 格式 Affinity Purified 控制 - Human kidney tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect TIMP-2 (C-terminus) using this Anti-TIMP-2 (C-terminus) Antibody validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected TIMP-2 in cervical carcinoma tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human TIMP-2. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody recognizes TIMP-2 at the C-terminus. 品种反应性 RabbitHumanMouseRatBovinePigHorseCanine Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with bovine, porcine, equine, canine, rabbit, and guinea pig based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003246
Entrez基因汇总 This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq]. 基因符号 - CSC-21K
- TIMP2
- TIMP-2
纯化方法 Affinity purified UniProt编号 - P16035
UniProt汇总 FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
SUBUNIT STRUCTURE: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
SUBCELLULAR LOCATION: Secreted.
INDUCTION: Down-regulated by TGFbeta1.
PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.
SEQUENCE SIMILARITIES: Belongs to the protease inhibitor I35 (TIMP) family. (View classification).
Contains 1 NTR domain.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.1 µg/mL of the antibody detected TIMP-2 in 10 µg of human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 50 µg
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下一件merck millipore产品：merck millipore,默克密理博,197331,Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem
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