merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5464,Anti-Synuclein Antibody, pan

  • merck millipore,默克密理博,AB5464,Anti-Synuclein Antibody, pan

    产品名称：Anti-Synuclein Antibody, pan
    产品型号：AB5464
    Detect Synuclein using this Anti-Synuclein Antibody, pan validated for use in WB, IH(P).

    merck millipore,默克密理博,AB5464,Anti-Synuclein Antibody, pan

  • 产品介绍
  • merck millipore,默克密理博,AB5464,Anti-Synuclein Antibody, pan

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5464
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Synuclein Antibody, pan
    产品信息
    格式 Serum
    演示 Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
    应用
    应用 Detect Synuclein using this Anti-Synuclein Antibody, pan validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000.

    Immunohistochemistry: 1:1,000 on frozen and paraffin embedded tissue.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Peptide corresponding to the amino acids 11-26 of human a, b, and g (82%)-synuclein protein. The peptide was chosen so that the antibody would recognize all three forms of synuclein.
    宿主 Rabbit
    特异性 Pan synuclein. Initial testing by immunohistochemistry indicates that the antibody staining pattern overlaps alpha, beta, and gamma-synuclein maps.
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_007308.1
    • NM_000345.2
    Entrez基因汇总 The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
    基因符号
    • Alpha-synuclein
    • SNCA
    • PD1
    • alpha-synuclein
    • NACP
    • PARK4
    • MGC110988
    • PARK1
    UniProt编号
    • O76070
    • P37840
    • Q16143
    UniProt汇总 FUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    SIZE: 134 amino acids; 14288 Da
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
    PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
    SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5464,Anti-Synuclein Antibody, pan

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