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品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1548 描述 Anti-HDAC11 Antibody Alternate Names - histone deacetylase 11
背景信息 HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. 产品信息 格式 Purified 控制 - Mouse Brain cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.09% NaN3. 应用 应用 Use Anti-HDAC11 Antibody (Rabbit Polyclonal Antibody) validated in WB, ELISA, IHC to detect HDAC11 also known as histone deacetylase 11. 主要应用 - Immunohistochemistry
- Western Blotting
- ELISA
应用说明 ELISA:
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).
Immunohistochemistry:
This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100).
生物信息 免疫原品种 The immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes HDAC11. 品种反应性 MouseHuman Species Reactivity Note Human, Mouse. Not tested in other species. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_079103
Entrez基因汇总 This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
基因符号 - EC 3.5.1.98
- HD11
- FLJ22237
纯化方法 Protein G chromatography UniProt编号 - Q96DB2
UniProt汇总 FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Ref.4
Catalytic activity Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
SUBUNIT STRUCTURE: Interacts with HDAC6. Ref.4
SUBCELLULAR LOCATION: Nucleus. Note= Predominantly nuclear.
TISSUE SPECIFICITY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
SEQUENCE SIMILARITY: Belongs to the histone deacetylase family.
SEQUENCE CAUTION:The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.
The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.
产品使用声明 质量保证 Western Blot Analysis:
Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. 包装信息 数量 100 µg
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