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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 09-267 描述 Anti-human Tks4 Antibody Alternate Names - adaptor protein HOFI
- Adapter protein HOFI
- Factor for adipocyte differentiation 49
- SH3 and PX domains 2B
背景信息 Tks4 (gene symbol SH3PXD2B) is a novel adaptor protein; also known as SH3 and PX domain-containing protein 2B, (Courtneidge, 2005). It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). Additionally, Tks4 may be involved in the recruitment of MT1-MMP and ECM degradation.
Tks4 is broadly expressed and localizes in the cytoplasm of the podosome.产品信息 格式 Purified 控制 - NIH3T3 cell lysate.
演示 Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3. 应用 应用 This Anti-human Tks4 Antibody is validated for use in WB, IP for the detection of human Tks4. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant protein containing amino acids 431-595 of human Tks4. 表位 a. a. 431-595 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody recognizes human Tks4. 品种反应性 MouseHuman Species Reactivity Note Human and mouse (76% homology). Predicted to cross react with rat (77% homology). Reactivity with other species has not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - A1X283
基因符号 - KIAA1295
- FAD49
- FLJ20831
- HOFI
纯化方法 Protein A purfied UniProt编号 - A1X283
UniProt汇总 FUNCTION: Binds a range of phosphoinositides including phosphatidylinositol 3,5-biphosphate and, to a lesser extent, phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 5-biphosphate. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation By similarity.
SUBCELLULAR LOCATION: Cytoplasm By similarity.
DOMAIN: The PX domain is required for binding phosphoinositides and can also bind to the third SH3 domain By similarity.
SEQUENCE SIMILARITIES: Belongs to the SH3PXD2 family.
Contains 1 PX (phox homology) domain.
Contains 4 SH3 domains.产品使用声明 质量保证 Evaluated on a representative lot by Immunoprecipitation followed by Western blot on NIH3T3 cell lysate using Anti-human Tks4. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 1 year from date of receipt. 包装信息 数量 100 µg
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