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品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Purified Polyclonal Antibody 描述 产品目录编号 06-172 品牌系列 Upstate
商名 - Upstate
描述 Anti-Na+/K+ ATPase α-3 Antibody 产品信息 格式 Purified 演示 0.1M Tris-HCl, pH 7.2, containing 0.02% sodium azide 应用 应用 Anti-Na+/K+ ATPase α-3 Antibody detects level of Na+/K+ ATPase α-3 & has been published & validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 Fusion protein derived the alpha 3 subunit containing residues 320-514 宿主 Rabbit 特异性 Na+/K+ ATPase α-3 同种型 IgG 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_152296
Entrez基因汇总 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. 基因符号 - Na
- ATP1A3
- MGC13276
- RDP
- IIIsubunit).
- DYT12
- +K
纯化方法 Protein A chromatography UniProt编号 - P13637
UniProt汇总 FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
SIZE: 1013 amino acids; 111749 Da
SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot on brain microsomal preparations 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 125 µg
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