merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

  • merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

    产品名称：Anti-Growth Associated Protein 43 Antibody, phosphoSer 41
    产品型号：AB5401-25UL
    This Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 is validated for use in WB for the detection of Growth Associated Protein 43.

    merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

  • 产品介绍
  • merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5401-25UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Growth Associated Protein 43 Antibody, phosphoSer 41
    Alternate Names
    • Neuromodulin
    • GAP-43
    背景信息 GAP-43, a common marker of differentiating neurons, is expressed at elevated levels by developing or regenerating neurons during axon growth. While GAP-43 is an integral membrane protein associated with the cytoplasmic surface of axonal growth cones (and synapses), it is absent from dendritic growth cones. In adult brain, GAP-43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. Phosphorylation of GAP-43 by PKC (at Ser41 on human, mouse, rat, and bovine GAP-43 or Ser42 on chicken and Xenopus GAP-43) is specifically correlated with certain forms of synaptic plasticity.
    产品信息
    格式 Affinity Purified
    控制
    • Synthetic peptide corresponding to amino acids surrounding the phosphoSer41 of rat GAP-43.
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 mg/mL BSA and 50% glycerol.
    应用
    应用 This Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 is validated for use in WB for the detection of Growth Associated Protein 43.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000 (43KDa band).

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids surrounding the phosphoSer41 of rat GAP-43. This is the site phosphorylated by protein kinase C.
    表位 phosphoSer 41
    宿主 Rabbit
    特异性 GAP-43 phosphoSer41. The labeling of the GAP-43 protein (~43kDa) in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. In some tissues the antibody may recognize a lower molecular weight band. This band is also detected by a pan GAP-43 antibody.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002045.2
    Entrez基因汇总 The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This encoded protein is considered a crucial component of an effective regenerative response in the nervous system.
    基因符号
    • neuromodulin
    • GAP43
    • PP46
    • Neuromodulin
    • B-50
    修改
    • Phosphorylation
    UniProt编号
    • P17677
    UniProt汇总 FUNCTION: SwissProt: P17677 # This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons.
    SIZE: 238 amino acids; 24803 Da
    SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
    PTM: Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
    SIMILARITY: SwissProt: P17677 ## Belongs to the neuromodulin family. & Contains 1 IQ domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
    包装信息
    数量 25 µL

    merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

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