- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS12 描述 Anti-GRK6 Antibody, clone 4B11.2 Alternate Names - G protein-coupled receptor kinase GRK6
- G protein-coupled receptor kinase 6
背景信息 G protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide 应用 应用 Detect GRK6 using this Anti-GRK6 Antibody, clone 4B11.2 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human GRK6. 克隆 4B11.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001004105
Entrez基因汇总 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]. 基因符号 - GPRK6
- GRK6
纯化方法 Protein G UniProt编号 - P43250
UniProt汇总 FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors.
CATALYTIC ACTIVITY: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
TISSUE SPECIFICTY: Widely expressed.
PTM: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected GRK6 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,SCR511,STEMCCA Cre-Excisable Constitutive Polycistronic (OKSM) Lentivirus Reprogramming Kit
下一件merck millipore产品：merck millipore,默克密理博,MAB4155A4,Anti-BCRP1 Antibody, clone 5D3, Alexa Fluor 488 conjugate
相关产品
merck millipore,默克密理博,MAB3211,Anti-Lamin A/C Antibody, clone JoL2
merck millipore,默克密理博,SF-1417,SOX10; Mouse, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,06-1076,Anti-IL-22 Antibody
merck millipore,默克密理博,5161,Penicillin G, Potassium Salt - CAS 113-98-4 - Calbiochem
merck millipore,默克密理博,MAB4155A4,Anti-BCRP1 Antibody, clone 5D3, Alexa Fluor 488 conjugate
merck millipore,默克密理博,MAB16985B,Anti-MCAM Antibody, clone P1H12, biotin conjugated
merck millipore,默克密理博,MAB2244,Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29
merck millipore,默克密理博,AB5401-25UL,Anti-Growth Associated Protein 43 Antibody, phosphoSer 41
merck millipore,默克密理博,579050,TAPI-0 - CAS 143457-40-3 - Calbiochem