merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5050P,Anti-NMDAR1 Splice Variant C2 Antibody

  • merck millipore,默克密理博,AB5050P,Anti-NMDAR1 Splice Variant C2 Antibody

    产品名称：Anti-NMDAR1 Splice Variant C2 Antibody
    产品型号：AB5050P
    Detect NMDAR1 Splice Variant C2 using this Anti-NMDAR1 Splice Variant C2 Antibody validated for use in IH & WB.

    merck millipore,默克密理博,AB5050P,Anti-NMDAR1 Splice Variant C2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5050P,Anti-NMDAR1 Splice Variant C2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5050P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-NMDAR1 Splice Variant C2 Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservatives.
    应用
    应用 Detect NMDAR1 Splice Variant C2 using this Anti-NMDAR1 Splice Variant C2 Antibody validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:2000 using ECL

    Immunohistochemistry: 1:1000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Peptide corresponding to the C-terminus of the rat NMDAR1 C2' splice variant.
    宿主 Rabbit
    特异性 Specific for the NMDAR1 containing the C2' splice variant insert. The antibody does not recognize the NMDAR1 subunits of the NMDA receptor that do not contain the C2' insert. By Western blot the antibody recognizes a protein with molecular weight of 120 kDa. Also labels a single higher molecular weight band that may be a posttranslationally modified form of the protein.
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_021569.2
    • NM_000832.5
    • NM_007327.2
    Entrez基因汇总 The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
    基因符号
    • NR1
    • GRIN1
    • Glutamate
    • NMDAR1
    • NMDA1
    UniProt编号
    • Q05586
    UniProt汇总 FUNCTION: SwissProt: Q05586 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
    SIZE: 938 amino acids; 105373 Da
    SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).
    PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
    SIMILARITY: SwissProt: Q05586 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 25 µg

    merck millipore,默克密理博,AB5050P,Anti-NMDAR1 Splice Variant C2 Antibody

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