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  • merck millipore,默克密理博,ABT58,Anti-phospho PKA-RII (Ser96) Antibody

  • merck millipore,默克密理博,ABT58,Anti-phospho PKA-RII (Ser96) Antibody

    产品名称：Anti-phospho PKA-RII (Ser96) Antibody
    产品型号：ABT58
    This Anti-phospho PKA-RII (Ser96) Antibody is validated for use in WB for the detection of phospho PKA-RII (Ser96).

    merck millipore,默克密理博,ABT58,Anti-phospho PKA-RII (Ser96) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABT58,Anti-phospho PKA-RII (Ser96) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, H, RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABT58
    Replaces 06-704
    描述 Anti-phospho PKA-RII (Ser96) Antibody
    Alternate Names
    • cAMP-dependent, regulatory, type II, alpha
    • PRKAR2A
    • protein kinase
    背景信息 cAMP-dependent protein kinase type II-alpha regulatory subunit (PKA-RIIα) is an enzymatic protein belonging to the cAMP-dependent kinase regulatory chain family, a group of regulatory proteins involved in the PKA signaling pathway. This pathway has been shown to have regulatory roles in development, growth, and mortality of various organisms. PKA-RIIα is a subunit of the PKA type II regulatory chain, one of two PKA isoforms, and is involved in the regulation of membrane interactions through its binding to anchoring proteins, such as MAP2 kinase. Before its activation with cAMP, the enzyme is comprised of two catalytic chains and two regulatory chains, which split into two catalytic monomers and one regulatory dimmer after interacting with cAMP.
    产品信息
    格式 Affinity Purified
    控制
    • Forskolin untreated and treated PC12 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
    应用
    应用 This Anti-phospho PKA-RII (Ser96) Antibody is validated for use in WB for the detection of phospho PKA-RII (Ser96).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to mouse PKA-RIIalpha phosphorylated at Ser96.
    表位 Phosphorylated Ser96 of PKA-RIIalpha
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The antibody recognizes PKA-RIIalpha when phosphorylated at Ser96.
    品种反应性 MouseHumanRat
    Species Reactivity Note Demonstrated to react with human and rat. Predicted to react with mouse based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_032950
    基因符号
    • PRKAR2
    • PRKAR2A
    • PKR2
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P12367
    UniProt汇总 FUNCTION: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

    SUBUNIT STRUCTURE: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4. Interacts with CBFA2T3 (by similarity).

    TISSUE SPECIFICTY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

    PTM: Phosphorylated by the activated catalytic chain.

    SEQUENCE SIMILARITIES: Belongs to the cAMP-dependent kinase regulatory chain family.

    Contains 2 cyclic nucleotide-binding domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in Forskolin untreated and treated PC12 cell lysates.

    Western Blot Analysis: 1 µg/mL of the antibody detected PKA-RIIalpha (Ser96) in 10 µg of Forskolin untreated and treated PC12 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABT58,Anti-phospho PKA-RII (Ser96) Antibody

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