merck millipore,默克密理博,MAB1287,Anti-Nuclear Ribonucleoprotein Antibody, clone 58-15

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H	IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB1287
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Nuclear Ribonucleoprotein Antibody, clone 58-15
Alternate Names	RNP
背景信息	snRNPs or small nuclear ribonucleoproteins, are particles that combine with pre-mRNA and various proteins to form spliceosomes (a type of large molecular complex). SnRNPs "recognize" the places along a strand of pre-mRNA and are essential in the removal of introns. These molecules are found within the cell's nucleus. The two essential components of snRNPs are protein molecules and RNA. The RNA found within each snRNP particle is known as small nuclear RNA, or snRNA. These molecules are usually about 150 nucleotides long. The snRNA is bound by a Ribonuclear protein (RNP) to activate its enzymatic activity. The precise beginnings and ends of introns on the primary transcripts are marked by signals so that they can be recognized and removed. The intron-boundary signals are recognized by a short bit of RNA found in curious RNA-protein complexes known as the small nuclear ribonucleoprotein particles - snRNPs, for short. At least four different kinds of snRNPs cooperate in most splicing. The RNA in these particles is like ribosomal RNA in that it is used directly, and has both an enzymatic and a structural role.

产品信息
格式	Purified
控制	Jurkat whole cell lysate, K-562 whole cell lysate
演示	Hybridoma supernatant, concentrated by ammonium sulfate. Buffer: PBS with 0.1% sodium azide.

应用
应用	This Anti-Nuclear Ribonucleoprotein Antibody, clone 58-15 is validated for use in IF, IH, IH(P) for the detection of Nuclear Ribonucleoprotein.
主要应用	Immunohistochemistry
应用说明	Indirect immunofluorescence: 1:20-1:30. Use 30-100 μl per well/slide. Immunohistochemistry in formalin fixed paraffin embedded tissues: requires citrate acid microwave or HIER pretreatment: 1:20-1:30 primary antibody dilution. Archival tissues will require more antibody than 24-48 fixed specimens. Optimal working dilutions must be determined by the end user.

生物信息
克隆	58-15
宿主	Mouse
特异性	Stains nuclear ribonucleoprotein particles (RNP) in human cells. Does not cross react with mouse RNP, other species not tested. RNP are 20-80nm dense nuclear particles. Highest labeling densities are found in RNP, but heterochromatin, euchromatin and nucleoli are also stained.
同种型	IgM
品种反应性	RatHuman
抗体类型	Monoclonal Antibody
非反应性品种	Mouse

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

包装信息
数量	100 µL

merck millipore,默克密理博,MAB1287,Anti-Nuclear Ribonucleoprotein Antibody, clone 58-15

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