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  • merck millipore,默克密理博,AB3252,Anti-c-myc Antibody

  • merck millipore,默克密理博,AB3252,Anti-c-myc Antibody

    产品名称：Anti-c-myc Antibody
    产品型号：AB3252
    Anti-c-myc Antibody is a Chicken Polyclonal Antibody for detection of c-myc also known as Proto-oncogene c-Myc & has been tested in IP, WB, ICC.

    merck millipore,默克密理博,AB3252,Anti-c-myc Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3252,Anti-c-myc Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBChAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3252
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-c-myc Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified chicken IgY. Liquid in PBS with 0.02% sodium azide.
    应用
    应用 Anti-c-myc Antibody is a Chicken Polyclonal Antibody for detection of c-myc also known as Proto-oncogene c-Myc & has been tested in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western blotting (ECL): 1:500

    Immunocytochemistry: 1:250

    Immunoprecipitation: 1:250

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide EQKLISEEDL from human c-myc.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Chicken
    特异性 c-myc
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002467.3
    Entrez基因汇总 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    基因符号
    • c-Myc
    • MYC
    • C-MYC
    UniProt编号
    • P01106
    UniProt汇总 FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    SIZE: 439 amino acids; 48804 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC.
    DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
    SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots, under sterile conditions, for up to 6 months. Freezing the antibody will result in loss of activity of approximately 50%.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB3252,Anti-c-myc Antibody

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