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  • merck millipore,默克密理博,07-719,Anti-acetyl-H2A.Z (Lys14) Antibody

  • merck millipore,默克密理博,07-719,Anti-acetyl-H2A.Z (Lys14) Antibody

    产品名称：Anti-acetyl-H2A.Z (Lys14) Antibody
    产品型号：07-719
    Anti-acetyl-H2A.Z (Lys14) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-H2A.Z (Lys14) also known as H2AZ histone, histone H2A.Z, Htz1 & has been validated in WB.

    merck millipore,默克密理博,07-719,Anti-acetyl-H2A.Z (Lys14) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-719,Anti-acetyl-H2A.Z (Lys14) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Yeast (S. cerevisiae)WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-719
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-acetyl-H2A.Z (Lys14) Antibody
    概述 Htz1 is the yeast homologue of the vertebrate histone variant H2A.Z
    Alternate Names
    • Htz1
    • H2A histone family, member Z
    • H2AZ histone
    • histone H2A.Z
    • histone H2A.Z
    产品信息
    格式 Affinity Purified
    应用
    应用 Anti-acetyl-H2A.Z (Lys14) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-H2A.Z (Lys14) also known as H2AZ histone, histone H2A.Z, Htz1 & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide containing the amino acids GA[AcK]DS, where [AcK] is acetyl-lysine 14 of yeast Htz1.
    宿主 Rabbit
    特异性 acetyl-Htz1 (Lys14)
    同种型 IgG
    品种反应性 Yeast (S. cerevisiae)
    Species Reactivity Note NOT human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002106.3
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
    基因符号
    • MGC117173
    • H2AFZ
    • H2A/z
    • H2A.Z
    • H2AZ
    • H2A.z
    修改
    • Acetylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P0C0S5
    UniProt汇总 FUNCTION: SwissProt: P0C0S5 # Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
    SIZE: 128 amino acids; 13553 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP (By similarity).
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. & Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity). & Not phosphorylated (By similarity).
    SIMILARITY: SwissProt: P0C0S5 ## Belongs to the histone H2A family.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-719,Anti-acetyl-H2A.Z (Lys14) Antibody

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