merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB011-A/13,Anti-Apolipoprotein A-I Antibody, clone A/13

  • merck millipore,默克密理博,MAB011-A/13,Anti-Apolipoprotein A-I Antibody, clone A/13

    产品名称：Anti-Apolipoprotein A-I Antibody, clone A/13
    产品型号：MAB011-A/13
    Anti-Apolipoprotein A-I Antibody, clone A/13 detects level of Apolipoprotein A-I & has been published & validated for use in ELISA, RIA.

    merck millipore,默克密理博,MAB011-A/13,Anti-Apolipoprotein A-I Antibody, clone A/13

  • 产品介绍
  • merck millipore,默克密理博,MAB011-A/13,Anti-Apolipoprotein A-I Antibody, clone A/13

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB011-A/13
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Apolipoprotein A-I Antibody, clone A/13
    Alternate Names
    • ApoAI
    产品信息
    格式 Purified
    演示 IgG fraction purified from mouse ascites by DEAE column chromatography. In 0.015 M potassium phosphate buffer with 0.15M NaCl, 0.1% sodium azide, pH 7.2.
    应用
    应用 Anti-Apolipoprotein A-I Antibody, clone A/13 detects level of Apolipoprotein A-I & has been published & validated for use in ELISA, RIA.
    主要应用
    • ELISA
    应用说明 Competitive RIA or EIA

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified human plasma Apo A-I.
    克隆 A/13
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Apolipoprotein A-I. No cross reactivity to Apo A-II or Apo B.

    AFFINITY CONSTANT:

    8 x 10E9 l/mol
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000039.1
    Entrez基因汇总 This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
    基因符号
    • Apo-AI
    • APOA1
    • ApoA-I
    • preproapolipoprotein
    • amyloidosis
    • MGC117399
    UniProt编号
    • P02647
    UniProt汇总 FUNCTION: SwissProt: P02647 # Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
    SIZE: 267 amino acids; 30778 Da
    SUBUNIT: Interacts with APOA1BP.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine.
    PTM: Palmitoylated.
    DISEASE: SwissProt: P02647 # Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant. & Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. In HDLD1 patients, ApoA-I fails to associate with HDL probably because of the faulty conversion of pro-ApoA-I molecules into mature chains, either due to a defect in the converting enzyme activity or a specific structural defect in Tangier ApoA-I. & Defects in APOA1 are a cause of systemic non-neuropathic amyloidosis [MIM:105200]; also known as amyloidosis VIII or Ostertag-type amyloidosis. It is an autosomal dominant disorder characterized by generalized amyloid deposition.
    SIMILARITY: SwissProt: P02647 ## Belongs to the apolipoprotein A1/A4/E family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Do not store below -20°C or in dry ice as precipitation may occur. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,MAB011-A/13,Anti-Apolipoprotein A-I Antibody, clone A/13

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