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经验配方 C₁₆H₁₇FN₃NaO₃ 描述 概述 A fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.). 产品目录编号 557305 品牌系列 Calbiochem®
同义词 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt 参考 参考 Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
Zhang, Q., et al. 2008. Cell Res. 18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.产品信息 形式 Light yellow Hill配方 C₁₆H₁₇FN₃NaO₃ 化学配方 C₁₆H₁₇FN₃NaO₃ Molar Mass 341.3 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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