merck millipore,默克密理博,MABC771,Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABC771,Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody
产品名称：Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody
产品型号：MABC771
This Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of SPHK1.

merck millipore,默克密理博,MABC771,Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABC771,Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABC771
描述	Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody
Alternate Names	SPK 1 Sphingosine kinase 1 SK 1
背景信息	Sphingosine kinase 1 (SK 1 or SPK 1), encoded by the gene name SPHK1 or SPHK or SPK, is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum. SPHK1 is widely expressed with highest levels found in adult liver, kidney, heart and skeletal muscle.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-SPHK1, clone EPR4293(2), Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of SPHK1.
主要应用	Flow Cytometry Western Blotting
应用说明	Flow Cytometry Analysis: A 1:10-100 dilution from a representative lot detected SPHK1 in permeabilized Raji cells . Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human SPHK1.
克隆	EPR4293(2)
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	SPK SPHK1 SPHK
纯化方法	Unpurified
UniProt编号	Q9NYA1

产品使用声明
质量保证	Evaluated by Western Blotting in Raji, JAR, HUVEC, and HT-1080 cell lysate. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected SPHK1 in Raji, JAR, HUVEC, and HT-1080 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.