merck millipore,默克密理愽
  • merck millipore,默克密理博,648485,TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

  • merck millipore,默克密理博,648485,TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

    产品名称：TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem
    产品型号：648485
    The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,648485,TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,648485,TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₂₁N₅O₃349085-38-7
    描述
    概述 A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
    产品目录编号 648485
    品牌系列 Calbiochem®
    同义词 HC-030031
    参考
    参考 Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
    McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
    产品信息
    CAS号 349085-38-7
    形式 White solid
    Hill配方 C₁₈H₂₁N₅O₃
    化学配方 C₁₈H₂₁N₅O₃
    Molar Mass 355.
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,648485,TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,SF-1458,FOXP1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,324521,Eeyarestatin I - CAS 412960-54-4 - Calbiochem


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