merck millipore,默克密理愽
  • merck millipore,默克密理博,373271,Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

  • merck millipore,默克密理博,373271,Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

    产品名称：Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem
    产品型号：373271
    The Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6, also referenced under CAS 1001753-24-7, controls the biological activity of Hec1/Nek2 Mitotic Pathway.

    merck millipore,默克密理博,373271,Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373271,Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₈N₂OS1001753-24-7
    描述
    概述 A cell-permeable INH1 (Cat. No. 373270) analog that contains a tri-, instead of di-, methylated aryl ring and exhibits significantly improved antiproliferative activity against MB231, MB468, HeLa, and K562 cells (IC50 = 1.7, 2.1, 2.4, and 2.5 µM, respectively) than INH1 (IC50 = 8.6, 10.5, 8.8, and 11.7 µM, respectively). Immobilized INH6 is shown to selectively pull down Hec1, but not Nek2, from HeLa cell extract. Treatment of HeLa cultures results in down-regulations of cellular Nek2 (6.25 µM , >4 h) and Hec1 (6.25 µM , >16 h), an increase in apoptotic G1 population (by 10-fold; 2.5 µM, 72 h), as well as increased mitotic abnormalities, including multipolar spindle formations and metaphase chromosome misalignment.
    产品目录编号 373271
    品牌系列 Calbiochem®
    同义词 N-(4-(2,4,6-Trimethylphenyl)-thiazol-2-yl)-benzamide, INH6
    参考
    参考 Qiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.
    产品信息
    CAS号 1001753-24-7
    形式 White solid
    Hill配方 C₁₉H₁₈N₂OS
    化学配方 C₁₉H₁₈N₂OS
    Molar Mass 322.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    安全信息
    S相 S: 22-24/25-36

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following resonstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373271,Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

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