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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1135 Replaces 04-397 描述 Anti-PDGFR Antibody, clone CH-3 Alternate Names - CD140b
- Platelet Derived Growth Factor Receptor Beta
- PDGF-R-beta
- PDGFR-beta
- Beta platelet-derived growth factor receptor
- Beta-type platelet-derived growth factor receptor
- CD140 antigen-like family member B
- Platelet-derived growth factor receptor 1
- PDGFR-1
背景信息 PDGFR (Platelet-Derived Growth Factor Receptor) is a receptor tyrosine kinase for the PDGF family of growth factors. PDGF homo and hetero- dimmers (dimer of A (17 kDa) and B (14 kDa) chains (AA, AB, or BB)) bind to the two structurally related a and b PDGF Receptors (PDGFRa and PDGFRb). The type A PDGF Receptor binds all three PDGFs with high affinity, whereas the type B PDGF Receptor is selective for PDGF-BB. This binding results in the dimerization of the receptor and the subsequent kinase activation of the receptor tyrosine kinase (RTK) and its autophosphorylation. These phosphorylations allow for various proteins, such as PI3 Kinase, PLCg, and Grb2, to bind through their SH2 domains and transduce signals into the cell. The activation of PDGFFR triggers the intracellular loop and activates Ras, Erk1/2, and ROS. PDGFb has been implicated in embryonic development, angiogenesis, and development of tumors of glial origin. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 Purified mouse monoclonal IgG1 in buffer containing 20 mM sodium phosphate, 250 mM NaCl, 0.1% NaN3, pH. 7.6 应用 应用 This Anti-PDGFR Antibody, clone CH-3 is validated for use in WB, ELISA, IH(P) for the detection of PDGFR. 主要应用 - ELISA
- Western Blotting
应用说明 ELISA: A previous lot of this antibody was used in ELISA.
Immunohistochemistry(paraffin): Representative images from a previous lot.
Optimal Staining of PDGF-A With Citrate pH 6.0 Epitope Retrieval: Rat Brain生物信息 免疫原品种 Recombinant Platelet-Derived Growth Factor Receptor 克隆 CH-3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1 品种反应性 RatHumanMouse Species Reactivity Note Human and mouse. Expected to react with rat based on sequence homology. 抗体类型 Monoclonal Antibody 纯化方法 Protein A purfied UniProt编号 - P09619
产品使用声明 质量保证 Routinely evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PDGFR on 10 μg of Jurkat lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at + 2-8 ° C in undiluted aliquots for up to 1 year from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,ABE335,Anti-FOXL2 Antibody
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