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merck millipore,默克密理博,FCMAB272F,Milli-Mark™ Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11
产品名称：Milli-Mark™ Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11
产品型号：FCMAB272F
Milli-Mark Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11 is an antibody against Cortactin (p80/85) for use in FC.
merck millipore,默克密理博,FCMAB272F,Milli-Mark™ Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB272F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11 Alternate Names - Oncogene EMS1
- Src substrate cortactin
- Amplaxin
背景信息 Cortactin is present as a p80 and p85 kDa protein in many cell types. The protein was first identified as being a major substrate of the tyrosine kinase pp60SRC. The main structural feature of the protein is that at the N-terminus there are five and a half 37-amino acid repeats, these appear to be responsible for the actin-binding. This repeat region occupies about a third of the protein. The repeat region is followed by a helical region and then a proline rich region and finally at the C-terminus, an SH3 domain. The proline rich domain is thought to bind the SH2 domain of v-src the viral version of the normal c-src known to phosphorylate cortactin. Cortactin bundles microfilaments and this bundling is inhibited by tyrosine phosphorylation. One pathway that activates the pathway leading to tyrosine phosphorylation of cortactin results from a cell adhesion molecule in brain micro-vessel endothelial cells, another is the growth factor, but presumably the very many mechanisms for pp60src activation would also result in cortactin phosphorylation and subsequent loss of actin binding. 产品信息 格式 FITC 控制 - HeLa cells
演示 Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-Cortactin (p80/85)-FITC Antibody, clone 4F11 is an antibody against Cortactin (p80/85) for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src
克隆 4F11 宿主 Mouse 特异性 Antibody recognizes Cortactin 同种型 IgG1 品种反应性 Human Species Reactivity Note Tested and passed on Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_005222
Entrez基因汇总 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. 基因符号 - 1110020L01Rik
- CTTN
- EMS1
- Amplaxin
- FLJ34459
纯化方法 Protein G Purified UniProt编号 - Q14247
UniProt汇总 FUNCTION: SwissProt: Q14247 # May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
SIZE: 550 amino acids; 61636 Da
SUBUNIT: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).
SIMILARITY: SwissProt: Q14247 ## Contains 7 cortactin repeats. & Contains 1 SH3 domain.产品使用声明 质量保证 Evaluated by flow cytometry using HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt. 包装信息 数量 100 tests
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