merck millipore,默克密理愽
  • merck millipore,默克密理博,526523,PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

  • merck millipore,默克密理博,526523,PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

    产品名称：PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem
    产品型号：526523
    The PIM1/2 Kinase Inhibitor V, also referenced under CAS 327033-36-3, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylatio More>>

    merck millipore,默克密理博,526523,PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,526523,PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₁H₆F₃NO₂S327033-36-3
    描述
    概述 A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 24 nM and 100 nM against Pim-1 and Pim-2, respectively), while exhibiting little or no activity against a panel of 58 other kinases (≤20% inhibition at 5 µM). One hour inhibitor treatment (0.5 µM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 µM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 µM with respective inhibitor).
    产品目录编号 526523
    品牌系列 Calbiochem®
    同义词 (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, SMI-4a
    参考
    参考 Lin,Y., et al. 2009. Blood In press.
    Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
    产品信息
    CAS号 327033-36-3
    形式 Light beige solid
    Hill配方 C₁₁H₆F₃NO₂S
    化学配方 C₁₁H₆F₃NO₂S
    Molar Mass 273.2
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,526523,PIM1/2 Kinase Inhibitor V - CAS 327033-36-3 - Calbiochem

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