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merck millipore,默克密理博,05-957,Anti-MAP Kinase 1/Erk 1 Antibody, CT, rabbit monoclonal
产品名称：Anti-MAP Kinase 1/Erk 1 Antibody, CT, rabbit monoclonal
产品型号：05-957
Detect MAP Kinase 1/Erk 1 using this Anti-MAP Kinase 1/Erk 1 Antibody, CT validated for use in IP & WB.
merck millipore,默克密理博,05-957,Anti-MAP Kinase 1/Erk 1 Antibody, CT, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Purified Monoclonal Antibody 描述 产品目录编号 05-957 品牌系列 Upstate
商名 - Upstate
描述 Anti-MAP Kinase 1/Erk 1 Antibody, CT, rabbit monoclonal 产品信息 格式 Purified 应用 应用 Detect MAP Kinase 1/Erk 1 using this Anti-MAP Kinase 1/Erk 1 Antibody, CT validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 synthetic peptide corresponding to rat Erk1, amino acids 346-380 (CGGPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP) 宿主 Rabbit 特异性 MAP Kinase 1/Erk1 同种型 IgG 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_053842, NM_017347
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. 基因符号 - ERT1
- MAPK1
- p38
- ERK
- P42MAPK
- ERK2
- p40
- PRKM1
- p41mapk
- PRKM2
- MAPK2
- p42-MAPK
- p41
- ERK-2
纯化方法 Protein A purfied UniProt编号 - P28482
UniProt汇总 FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
COFACTOR: Magnesium (By similarity).
SIZE: 360 amino acids; 41390 Da
SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot in RIPA lysates of 3T3/NIH cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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