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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC Rb Purified Polyclonal Antibody 描述 产品目录编号 AB5028 Replaces CBL98 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Endorphin β Antibody 产品信息 格式 Purified 演示 Purified immunoglobulin Liquid. Contains 0.1% sodium azide as a preservative. 应用 应用 Anti-Endorphin Antibody, β is an antibody against Endorphin for use in IH, RIA. 主要应用 - Immunohistochemistry
不建议的应用 - Immunohistochemistry (Paraffin)
应用说明 Immunohistochemistry: 1:500-1:1,000 using immunofluorescence and 1:5,000-1:10,000 for indirect avidin-biotin.
Not recommended for traditional formalin fixed paraffin tissues. 4% formalin fixed, resin embedded tissues can be used. Antibodies should be diluted in simple solutions (PBS plus 1% BSA) only. Blocking should not contain serum.
RIA: 1:10,000; sensitivity 120 pg/sample; IC50 - 1 ng/sample)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide (H-Thy-Gly-Gly-Phe-Met-Thr-Ser-Lys-
Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-
Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH) from human beta-endorphin conjugated to thyroglobulin.宿主 Rabbit 特异性 Beta-endorphin. Cross reactivity: Met-enkephalin 0.03%, Leu-enkephalin 0.02% and beta-Lipotropin 0.34%. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001035256.1
- NM_000939.2
Entrez基因汇总 This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. 基因符号 - gamma-MSH
- POMC
- pro-ACTH-endorphin
- adrenocorticotropin
- beta-LPH
- POC
- gamma-LPH
- LPH
- ACTH
- corticotropin
- beta-endorphin
- beta-MSH
- alpha-MSH
- pro-opiomelanocortin
- proopiomelanocortin
- Pro-opiomelanocortin
- corticotropin-lipotrophin
- NPP
- MSH
- met-enkephalin
- CLIP
UniProt编号 - P01189
UniProt汇总 FUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates.
SIZE: 267 amino acids; 29424 Da
TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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