merck millipore,默克密理愽
  • merck millipore,默克密理博,529599,PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

  • merck millipore,默克密理博,529599,PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

    产品名称：PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem
    产品型号：529599
    A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux in Syk MASA-expressing  More>>

    merck millipore,默克密理博,529599,PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,529599,PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₂₃N₅956026-24-7
    描述
    概述 A cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
    产品目录编号 529599
    品牌系列 Calbiochem®
    同义词 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor
    参考
    参考 Miller, A.L., et al. 2009. J. Immunol. 182, 988.
    Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
    产品信息
    CAS号 956026-24-7
    形式 Off-white powder
    Hill配方 C₁₈H₂₃N₅
    化学配方 C₁₈H₂₃N₅
    Molar Mass 309.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,529599,PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

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