merck millipore,默克密理博,422175,L-165,041 - CAS 79558-09-1

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merck millipore,默克密理博,422175,L-165,041 - CAS 79558-09-1 - Calbiochem
产品名称：L-165,041 - CAS 79558-09-1 - Calbiochem
产品型号：422175
A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ).

merck millipore,默克密理博,422175,L-165,041 - CAS 79558-09-1 - Calbiochem

产品介绍

merck millipore,默克密理博,422175,L-165,041 - CAS 79558-09-1 - Calbiochem

重要规格表

经验配方	CAS号
C₂₂H₂₆O₇	79558-09-1

描述
概述	A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
产品目录编号	422175
品牌系列	Calbiochem®
同义词	Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

参考
参考	Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

参考

Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.

产品信息
CAS号	79558-09-1
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₂H₂₆O₇
化学配方	C₂₂H₂₆O₇
Molar Mass	402.4
可逆	N
结构配方图像

生物信息
主靶	Peroxisome proliferator activator receptor δ (PPAR@delta;)
主靶K_i	6 nM for hPPARδ and 730 nM for hPPARγ
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or Aqueous NaOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.