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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Ch Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3535 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-α-1-Antitrypsin Antibody 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-α-1-Antitrypsin Antibody is an antibody against α-1-Antitrypsin for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Immunoblotting: 1:1,000-1:5,000
ELISA: 1:1,000-1:5,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptides. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Chicken 特异性 Alpha-1 antitrypsin. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001002236.1
- NM_000295.3
- NM_001002235.1
Entrez基因汇总 Alpha-1-antitrypsin is a protease inhibitor, deficiency of which is associated with emphysema and liver disease. The protein is encoded by a gene (PI) located on the distal long arm of chromosome 14.[supplied by OMIM] 基因符号 - A1A
- SERPINA1
- PRO2209
- PI1
- MGC23330
- alpha-1-antitrypsin
- PRO2275
- A1AT
- AAT
- MGC9222
- PI
UniProt编号 - P01009
UniProt汇总 FUNCTION: SwissProt: P01009 # Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity agaisnt insulin and plasmin.
SIZE: 418 amino acids; 46737 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Plasma.
DOMAIN: SwissProt: P01009 The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
PTM: Several isomers are observed, resulting from the combination of different N-linked glycan structures and mature N-terminus. N- linked glycan at Asn-107 is alternatively di-antennary, tri- antennary or tetra-antennary, whereas glycan at Asn-70 is di- antennary with trace amounts of tri-antennary, and glycan at Asn- 271 is exclusively di-antennary. The structure of the antennas is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennas are fucosylated, which forms a Lewis-X determinant. & Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.
DISEASE: SwissProt: P01009 # The major physiological function of AAT is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). A hereditary deficiency of AAT, is associated with a 20-30 fold increased risk of developing chronic obstructive pulmonary disease. & Deficiency of the normal inhibitor in individuals homozygous for allele Z or M-Malton can result in the development of chronic emphysema or infantile liver cirrhosis. & Variant Pittsburgh is the cause of bleeding diathesis.
SIMILARITY: Belongs to the serpin family.
MISCELLANEOUS: The aberrant form is found in the plasma of chronic smokers, and persists after smoking is ceased. It can still be found ten years after smoking has ceased.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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