merck millipore,默克密理博,06-1358,Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H, B	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	06-1358
描述	Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody
Alternate Names	Histone H1.4 Histone H1b
背景信息	H1.4 is one of four variants of histone H1 (H1.2-H1.5) that is found in somatic cells. The H1 histones may function as linker proteins binding DNA via their GH domain, and enabling the wrapping of DNA around the core nucleosomal structure formed from the association of H2A, H2B, H3, and H4. In response to various stimuli, histones undergo a number of post-translational modifications (PTM) including acetylation, phoshorylation, and methylation. Previous studies have suggested that H1.4 may be phosphorylated during mitosis and interphase resulting in increased transcription of target genes by RNA polymerase I and II, and therefore this PTM on H1.4 may have implications for cell growth. H1.4 may also undergo acetylation of its N-terminal lysine residues. Often, it is the pattern of different modifications on several histone residues that alter chromatin and affect gene expression, rather than modification of single residues.

产品信息
格式	Affinity Purified
控制	Calf thymus histone extract
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Use Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody (Rabbit Polyclonal Antibody) validated in WB & DB to detect acetyl (Lys34) phospho (Ser36) Histone H1 also known as Histone H1b.
主要应用	Western Blotting
应用说明	Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with acetyl (Lys34) phospho (Ser36) Histone H1.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human Histone H1 acetylated at Lys34 and phosphorylated at Ser36.
表位	Acetylated Lys34 and phosphorylated Ser36
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes Histone H1 acetylated at Lys34 and phosphorylated at Ser36.
品种反应性	HumanBovine
Species Reactivity Note	Demonstrated to react with Bovine and Human. Predicted to react with Canine and Rhesus macaque based on 100% sequence homology. Other homologies: Mouse and Rat (90% sequence homology).
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_005312
基因符号	H1F4 HIST1H1E
纯化方法	Affinity purified
UniProt编号	P10412

产品使用声明
质量保证	Evaluated by Western Blot in calf thymus histone extract. Western Blot Analysis: A 1:37 dilution of this antibody detected Histone H1 on 10 µg of calf thymus histone extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	200 µL

merck millipore,默克密理博,06-1358,Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody

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