merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody

  • merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody

    产品名称：Anti-Connective Tissue Growth Factor Antibody
    产品型号：07-1386
    Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.

    merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBGtPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1386
    描述 Anti-Connective Tissue Growth Factor Antibody
    Alternate Names
    • insulin-like growth factor-binding protein 8
    • Hypertrophic chondrocyte-specific protein 24
    • connective tissue growth factor
    背景信息 Connective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells.
    产品信息
    格式 Purified
    控制
    • Untreated and TGFb1 treated NRK cell lysates
    演示 Purified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide.
    应用
    应用 Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to the mature chain of human Connective tissue growth factor.
    表位 Mature chain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Goat
    特异性 This antibody recognizes the mature chain of Connective tissue growth factor.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001892.1
    Entrez基因汇总 The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq].
    基因符号
    • NOV2
    • CTGF
    • CCN2
    • HCS24
    • IGFBP8
    纯化方法 Protein G purfied
    UniProt编号
    • P29279
    UniProt汇总 FUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

    SUBCUNIT STRUCTURE: Monomer.

    SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix By similarity. Secreted By similarity.

    SEQUENCE SIMILARITIES: Belongs to the CCN family.

    Contains 1 CTCK (C-terminal cystine knot-like) domain.

    Contains 1 IGFBP N-terminal domain.

    Contains 1 TSP type-1 domain.

    Contains 1 VWFC domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates.

    Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody

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