merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated

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merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem
产品名称：PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem
产品型号：476485
The PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicatio More>>

merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem

产品介绍

merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem

重要规格表

经验配方
C₅₃H₁₀₀N₂₀O₁₂

描述
概述	Heat-stable protein kinase inhibitor (PKI) peptide sequence (14 - 22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (K_i = 36 nM) of cAMP-dependent protein kinase.
产品目录编号	476485
品牌系列	Calbiochem®
同义词	PKI 14-22 Amide, Cell-Permeable, Myr-GRTGRRNAI-NH₂, Myristoylated Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Protein Kinase A Inhibitor 14-22 Amide, PKA Inhibitor XIII

参考
参考	Paman, K., et al. 1998. J. Lipid Res. 39, 1091. Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289. Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648. Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461. Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263. Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982. Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903. Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304. Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.

参考

Paman, K., et al. 1998. J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289.
Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648.
Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461.
Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263.
Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903.
Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304.
Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.

产品信息
具有ATP竞争性	N
形式	Lyophilized
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₅₃H₁₀₀N₂₀O₁₂
化学配方	C₅₃H₁₀₀N₂₀O₁₂
Molar Mass	1209.5
吸湿	Hygroscopic
肽序列	Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
可逆	N

生物信息
主靶	cAMP-dependent protein kinase
主靶K_i	36 nMf or cAMP-dependent protein kinase
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	H₂O
肽序列	Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem

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