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Uni Prot编号 Q15746, O75116, Q16513, O75582, P51812, P17612, P23443 描述 产品目录编号 19-164 品牌系列 Upstate
商名 - Upstate
描述 HA1077 产品信息 演示 C14H17N3O2S2HCl 应用 主要应用 - Kinase Assay
应用说明 Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. 生物信息 Entrez基因编号 - NM_004850.3
Entrez基因汇总 This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. 基因符号 - KIAA0619
- ROCK2
UniProt编号 - Q15746
- O75116
- Q16513
- O75582
- P51812
- P17612
- P23443
UniProt汇总 FUNCTION: SwissProt: Q16513 # Exhibits a preference for highly basic protein substrates (By similarity).
SIZE: 984 amino acids; 112035 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
DOMAIN:SwissProt: Q16513 The C1 domain does not bind the diacylglycerol (DAG).
PTM: Autophosphorylated. & Activated by limited proteolysis with trypsin (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 4°C 包装信息 数量 5 mg
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