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merck millipore,默克密理博,04-283,Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3
产品名称：Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3
产品型号：04-283
Detect phospho-EGFR (Tyr845) using this Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3 validated for use in ELISA, IC, IP & WB.
merck millipore,默克密理博,04-283,Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ELISA, ICC M Purified Monoclonal Antibody 描述 产品目录编号 04-283 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3 Alternate Names - ERBB1
- ERBB
产品信息 格式 Purified 控制 - Includes EGF treated Hep2G cell lysate as a positive control
演示 100 µg of mouse monoclonal IgG1 lyophilized in 2X PBS containing 0.09% sodium azide, PEG, and sucrose 应用 应用 Detect phospho-EGFR (Tyr845) using this Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3 validated for use in ELISA, IC, IP & WB. 主要应用 - Western Blotting
- ELISA
- Immunocytochemistry
生物信息 免疫原品种 KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyr 845 in human EGFR. 克隆 12A3 宿主 Mouse 特异性 Recognizes phosphorylated EGFR on Tyrosine 845. 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_201284.1
- NM_005228.3
- NM_201282.1
- NM_201283.1
基因符号 - mENA
- EGFR
- ERBB1
- ERBB
修改 - Phosphorylation
纯化方法 Subsequent thiophilic adsorption and size exclusion chromatography UniProt编号 - P00533
UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
SIZE: 1210 amino acids; 134277 Da
SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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