- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB2930 Replaces 04-434 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Bax Antibody, a.a. 43-61 hBax Alternate Names - Bcl-2-associated X Protein
背景信息 BAX is one of the pro-apoptotic members of the Bcl-2 family. BAX is assumed to exert at least part of its apoptosis-inducing function by facilitating mitochondrial permeability transition pore opening, a process that is supposedly antagonized by the anti-apoptotic members Bcl-2 and Bcl-XL by the ability to form hetero-dimers. 产品信息 格式 Serum 演示 Whole serum without preservatives. 应用 应用 Detect Bax using this Anti-Bax Antibody, a.a. 43-61 hBax validated for use in WB, IP, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoblotting: Recommended antibody dilution 1:2000-5000
Immunoprecipitation: Recommended antibody dilution 1:150
Immunohistochemistry: Recommended antibody dilution 1:800; frozen, 4% PFA fixed sections
Optimal dilutions must be determined by end-user.生物信息 免疫原品种 Peptide against human Bax aa 43-61 表位 a.a. 43-61 hBax 宿主 Rabbit 特异性 AB2930 recognizes human Bax protein; sequence used is conserved in alpha, beta, sigma, epsilon, psi isoforms, cross reactivity to other species is untested. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_138765.2
- NM_004324.3
- NM_138761.2
- NM_138763.2
- NM_138764.2
Entrez基因汇总 The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. 基因符号 - BAX
UniProt编号 - Q07814
UniProt汇总 FUNCTION: SwissProt: Q07814 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.
SIZE: 41 amino acids; 4678 Da
SUBUNIT: Interacts with HN.
SUBCELLULAR LOCATION: Cytoplasm.
DOMAIN: SwissProt: Q07815
DISEASE:SwissProt: Q07812 # Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.
SIMILARITY: SwissProt: Q07815 ## Belongs to the Bcl-2 family. | Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. | P55269 ## Belongs to the Bcl-2 family. | Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C for up to 12 months from date of receipt. Avoid multiple freeze thaws. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,07-2178,Anti-Abl interactor 1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,MAB858-3,Anti-RSV Antibody, nucleoprotein, clone 130-12H
相关产品
merck millipore,默克密理博,07-1386,Anti-Connective Tissue Growth Factor Antibody
merck millipore,默克密理博,324393,Anti-Dopamine D₂ Receptor Rabbit pAb
merck millipore,默克密理博,OP40,Anti-Pan-Ras (Ab-3) Mouse mAb (RAS 10)
merck millipore,默克密理博,476485,PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem
merck millipore,默克密理博,07-2178,Anti-Abl interactor 1 Antibody
merck millipore,默克密理博,MAB858-3,Anti-RSV Antibody, nucleoprotein, clone 130-12H
merck millipore,默克密理博,71554,pET-52b(+) DNA - Novagen
merck millipore,默克密理博,19-164,HA1077
merck millipore,默克密理博,04-283,Anti-phospho-EGFR (Tyr845) Antibody, clone 12A3
merck millipore,默克密理博,AB9496,Anti-Trace Amine Receptor 3 Antibody