merck millipore,默克密理博,218697,Casein Kinase II Inhibitor I - CAS 17374-26-4

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Merck Millipore 默克密理愽

merck millipore,默克密理博,218697,Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem

经验配方	CAS号
C₆HBr₄N₃	17374-26-4

描述
概述	A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC₅₀ = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC₅₀ < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC₅₀ = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC₅₀ = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218708) in DMSO, is also available.
产品目录编号	218697
品牌系列	Calbiochem®
同义词	TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor

参考
参考	Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645. Sarno, S., et al. 2003. Biochem. J. 374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129. Ruzzene, M., et al. 2002. Biochem. J. 364, 41. Sarno, S., et al. 2001. FEBS Lett. 496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.

生物信息
主靶	CK2 rat liver, human recombinant
主靶IC₅₀	900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; < 1 µM for DYRK1a
纯度	≥99% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,218697,Casein Kinase II Inhibitor I - CAS 17374-26-4 - Calbiochem

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