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merck millipore,默克密理博,AB3442,Anti-CREB Antibody, pSer133
产品名称：Anti-CREB Antibody, pSer133
产品型号：AB3442
Anti-CREB Antibody, pSer133 is a Rabbit Polyclonal Antibody for detection of CREB also known as CREB-1, cAMP-response Element-binding Protein-1 & has been validated in WB.
merck millipore,默克密理博,AB3442,Anti-CREB Antibody, pSer133
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, Mk WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB3442 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CREB Antibody, pSer133 Alternate Names - cAMP-response Element-binding Protein-1
- CREB-1
产品信息 格式 Serum 演示 Rabbit serum. Liquid. The antibody has been preabsorbed with unphosphorylated peptide. Contains 0.01% sodium azide. 应用 应用 Anti-CREB Antibody, pSer133 is a Rabbit Polyclonal Antibody for detection of CREB also known as CREB-1, cAMP-response Element-binding Protein-1 & has been validated in WB. 主要应用 - Western Blotting
应用说明 Immunoblotting: 1:500-1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Phosphopeptide conjugated to KLH. 表位 pSer133 宿主 Rabbit 特异性 Recognizes phosphorylated Serine133 in cAMP response element binding protein (CREB). By immunoblotting the antibody shows a 5-10 fold increase in staining of a 43 kDa protein after treatment of cells with agents that increase intracellular cAMP. The antibody also recognizes phosphorylated ATF-1 due to a common epitope. The antibody has been preabsorbed with unphosphorylated peptide and will prove to be useful for the investigation of CREB phosphorylation. 品种反应性 RatHumanMouseMonkey 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_134442.2
- NM_004379.2
Entrez基因汇总 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. 基因符号 - CREB
- CREB1
- MGC9284
修改 - Phosphorylation
UniProt编号 - P16220
UniProt汇总 FUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
SIZE: 341 amino acids; 36688 Da
SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
SUBCELLULAR LOCATION: Nucleus.
PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze-thaw cycles. 包装信息 数量 100 µL
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