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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, ELISA, ICC, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5682 Replaces AB9620 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neurogenin-2 Antibody Alternate Names - Atonal Protein Homolog 4
- MATH4a (ms)
- ATH 4a
- Atoh4
- Ngn2
背景信息 Neurogenin 2 (NGN2) is a helix-loop-helix class of transcription factor. Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors, including Neurogenin 2 and a decrease in the activity of Hes and Id factors. bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate. Neurog2 controls neurogenesis in the embryonic cerebral cortex directly induces the expression of the small GTP-binding protein Rnd2 in newly generated mouse cortical neurons before they initiate migration. 产品信息 格式 Affinity Purified 控制 - Human brain Lysate.
演示 Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives. 应用 应用 This Anti-Neurogenin-2 Antibody is validated for use in ELISA, IC, IH, IH(P), WB for the detection of Neurogenin-2. 主要应用 - Western Blotting
- ELISA
- Immunocytochemistry
- Immunohistochemistry
应用说明 Western blot: 1-10 μg/mL using ECL.
Immunocytochemistry: Cat. # AB5682 detected Neurogenin-2 in PC12 cells at 1:500 dilution. It was also detected in paraformaldehyde-fixed differentiated human neural stem cells.
ELISA: 0.5-1 μg/mL using 1 mg/mL control peptide (Catalog Number AG352) per well.
Immunohistochemistry on paraffin sections has been reported by Lamolet, B. et al. (2004)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide, amino acids 85-97 of mouse Neurogenin 2. 宿主 Rabbit 特异性 Recognizes Neurogenin 2 (MATH4a), a Helix-loop-helix class of transcription factor. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_024019.2
Entrez基因汇总 Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells.[supplied by OMIM] 基因符号 - Neurogenin-2
- NEUROG2
- ATOH4
- ngn-2
- NGN2
- MGC46562
- Math4A
- Atoh4
UniProt编号 - Q9H2A3
UniProt汇总 FUNCTION: SwissProt: Q9H2A3 # Involved in neurogenesis (By similarity).
SIZE: 272 amino acids; 28621 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: SwissProt: Q9H2A3 ## Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µg
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