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merck millipore,默克密理博,06-969,Anti-STAT5B Antibody
产品名称：Anti-STAT5B Antibody
产品型号：06-969
Detect STAT5B also known as signal transducer & activator of transcription 5B with Anti-STAT5B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP & WB.
merck millipore,默克密理博,06-969,Anti-STAT5B Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, Av, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-969 品牌系列 Upstate
商名 - Upstate
描述 Anti-STAT5B Antibody 产品信息 格式 Serum 演示 rabbit antiserum 应用 应用 Detect STAT5B also known as signal transducer & activator of transcription 5B with Anti-STAT5B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide (MDSQWIPHAQS) corresponding to amino acids 776-786 of mouse STAT5B 宿主 Rabbit 特异性 STAT5B 同种型 IgG 品种反应性 RatAvianHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_012448
Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. 基因符号 - STAT5
- STAT5B
纯化方法 Antiserum UniProt编号 - P51692
UniProt汇总 FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SIZE: 787 amino acids; 89866 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
PTM: Tyrosine phosphorylated (By similarity).
DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Nb2-SP cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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