merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4425,Anti-PDX-1 Antibody, clone 6F6.1

  • merck millipore,默克密理博,MAB4425,Anti-PDX-1 Antibody, clone 6F6.1

    产品名称：Anti-PDX-1 Antibody, clone 6F6.1
    产品型号：MAB4425
    Anti-PDX-1 Antibody, clone 6F6.1 is a mouse monoclonal antibody for detection of PDX-1 also known as Pancreas Duodenum Homeobox-1, insulin promoter factor 1 homeodomain transcription factor & has been More>>

    merck millipore,默克密理博,MAB4425,Anti-PDX-1 Antibody, clone 6F6.1

  • 产品介绍
  • merck millipore,默克密理博,MAB4425,Anti-PDX-1 Antibody, clone 6F6.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4425
    描述 Anti-PDX-1 Antibody, clone 6F6.1
    Alternate Names
    • Islet/duodenum homeobox-1
    • Pancreas Duodenum Homeobox-1
    • insulin promoter factor 1, homeodomain transcription factor
    • pancreatic-duodenal homeobox factor 1
    • pancreas/duodenum homeobox protein 1
    • Insulin upstream factor 1
    • Glucose-sensitive factor
    • somatostatin transcription factor 1
    • Somatostatin-transactivating factor 1
    • Insulin promoter factor 1
    背景信息 Pancreas/duodenum homeobox protein 1 (PDX-1) belongs to the homeodomain-containing transcription factor family. PDX-1 is a critical factor in the processes of development and differentiation of the pancreas, specifically through the designation of early pancreatic epithelium, allowing it to proliferate, branch and ultimately differentiate. It has been shown to stimulate gene transcription for insulin, islet amyloid polypeptide, glucokinase, glucose transporter type 2, and somatostatin. PDX-1 also serves to regulate beta cells past development and into the adult stage. Defects in PDX-1 are the cause of several pancreatic diseases including; pancreatic agenesis, maturity-onset diabetes of the young type 4, and non-insulin-dependent diabetes mellitus. Up-regulation of PDX-1 in adult tissue has been associated with pancreatitis and pancreatic cancer. PDX-1 is expressed in the duodenum and pancreas tissues. It is also found in pancreatic progenitor cells.
    产品信息
    格式 Purified
    控制
    • Panc-1 cell lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-PDX-1 Antibody, clone 6F6.1 is a mouse monoclonal antibody for detection of PDX-1 also known as Pancreas Duodenum Homeobox-1, insulin promoter factor 1 homeodomain transcription factor & has been validated in WB.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:400 dilution from a previous lot detected PDX-1 in islet of langerhans of normal pancreas tissue.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human PDX-1.
    克隆 6F6.1
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000200
    Entrez基因汇总 The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq].
    基因符号
    • IUF-1
    • PDX1
    • IPF1
    • IDX-1
    • GSF
    • IUF1
    • IPF-1
    • STF-1
    • MODY4
    • PDX-1
    纯化方法 Protein G Purified
    UniProt编号
    • P52945
    UniProt汇总 FUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

    SIZE: 283 amino acids; 30771 Da

    SUBUNIT: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

    DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarity). & The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein- protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By similarity).

    PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.

    DISEASE: Defects in PDX1 are a cause of pancreatic agenesis [MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant. & Defects in PDX1 are the cause of maturity onset diabetes noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II. & Defects in PDX1 are the cause of maturity onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.

    SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. ...
    产品使用声明
    质量保证 Evaluated by Western Blot in Panc-1 cell lysate.

    Western Blot Analysis: A 1:1,000 dilution of this antibody detected PDX-1 in 10 µg of Panc-1 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB4425,Anti-PDX-1 Antibody, clone 6F6.1

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