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  • merck millipore,默克密理博,07-213,Anti-dimethyl-Histone H4 (Arg3) Antibody

  • merck millipore,默克密理博,07-213,Anti-dimethyl-Histone H4 (Arg3) Antibody

    产品名称：Anti-dimethyl-Histone H4 (Arg3) Antibody
    产品型号：07-213
    Anti-dimethyl-Histone H4 (Arg3) Antibody is a Rabbit Polyclonal Antibody for detection of dimethyl-Histone H4 (Arg3) also known as H4 histone family member A, histone 1 H4a & has been validated in WB.

    merck millipore,默克密理博,07-213,Anti-dimethyl-Histone H4 (Arg3) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-213,Anti-dimethyl-Histone H4 (Arg3) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Inv, H, VrtWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-213
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-dimethyl-Histone H4 (Arg3) Antibody
    Alternate Names
    • histone cluster 1, H4a
    • H4 histone family, member A
    • histone 1, H4a
    • histone 1
    • H4a
    背景信息 Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Acetylation of histone H4 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs).
    产品信息
    格式 Affinity Purified
    控制
    • Acid extracted proteins from HeLa cells.
    演示 Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.2 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide, 5 mg/mL BSA and 30% glycerol.
    应用
    应用 Anti-dimethyl-Histone H4 (Arg3) Antibody is a Rabbit Polyclonal Antibody for detection of dimethyl-Histone H4 (Arg3) also known as H4 histone family member A, histone 1 H4a & has been validated in WB.
    主要应用
    • Western Blotting
    应用说明 Methylation/Western Blot Assay: Reported by an independent laboratory to detect Histone H4 methylated in vitro by recombinant PRMT1 and detected by western blot analysis.
    生物信息
    免疫原品种 BSA-conjugated synthetic peptide (SG[me2R]GKGGKG-C) corresponding to amino acids 1-9 of Histone H4 with a C-terminal cysteine added to facilitate conjugation. The immunizing sequence is conserved from Tetrahymena to human.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes methylated Histone H4 (Arg3), MW 10 kDa. Addition of 0.1% Tween®-20 in western blot buffers results in the detection of additional proteins at 17 kDa (possibly methylated Histone H2a), 34 kDa and 80 kDa. Specificity demonstrated by ELISA using methylated and unmethylated Histone H4 peptides. The antibody does not detect recombinant Histone H3 purified from E. coli.
    同种型 IgG
    品种反应性 InvertebratesHumanVertebrates
    Species Reactivity Note Human. Broad species cross-reactivity is expected.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_778224
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
    基因符号
    • H4/E
    • HIST1H4A
    • H4/J
    • HIST1H4F
    • HIST1H4L
    • H4FN
    • H4FA
    • H4FH
    • HIST1H4H
    • H4F2
    • H4FM
    • H4/A
    • H4FK
    • H4FG
    • HIST2H4
    • H4FB
    • H4/K
    • HIST1H4I
    • H4/N
    • HIST1H4B
    • H4FE
    • H4/M
    • H4/a
    • HIST1H4E
    • HIST4H4
    • HIST2H4A
    • H4FC
    • H4FI
    • H4/H
    • HIST1H4C
    • H4/G
    • HIST1H4K
    • H4FJ
    • H4FD
    • H4/I
    • H4/B
    • H4/D
    • H4/C
    • HIST1H4J
    • HIST1H4D
    修改
    • Methylation
    纯化方法 Immunoaffinity chromatography
    UniProt编号
    • P62805
    UniProt汇总 FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    SIZE: 103 amino acids; 11367 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
    SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
    产品使用声明
    质量保证 Western Blot Analysis: A 1:500-1:2000 dilution of this antibody detected methylated Histone H4 in acid-extracted proteins from HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-213,Anti-dimethyl-Histone H4 (Arg3) Antibody

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