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merck millipore,默克密理博,14-861,CHIP Protein, recombinant, 50 µg
产品名称：CHIP Protein, recombinant, 50 µg
产品型号：14-861
Recombinant fusion protein containing human CHIP with an N-terminal His-tag, expressed in E. coli. For use in Activity Assays.
merck millipore,默克密理博,14-861,CHIP Protein, recombinant, 50 µg
- 产品介绍
重要规格表
主要应用 Entrez基因编号 品种 Uni Prot编号 ACT NM_005861.2 Human Q9UNE7 描述 产品目录编号 14-861 品牌系列 Upstate
商名 - Upstate
描述 CHIP Protein, recombinant, 50 µg 概述 Recombinant fusion protein containing human CHIP with an N-terminal His-tag, expressed in E. coli. Alternate Names - Carboxyl terminus of Hsp70-Interacting Protein, STIP1 homology and U-box containing protein 1
产品信息 演示 50 µg recombinant CHIP in 50 µL of 50mM Tris-HCl, pH 7.5, 270mM Sucrose, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.02% Brij-35, 0.2mM PMSF, and 1mM Benzamidine. Frozen solution. 应用 应用 Recombinant fusion protein containing human CHIP with an N-terminal His-tag, expressed in E. coli. For use in Activity Assays. 主要应用 - Activity Assay
生物信息 纯度 ~90% by SDS PAGE and Coomassie blue staining. 来源 Expressed in E. coli 品种 Human Entrez基因编号 - NM_005861.2
基因符号 - UBOX1
- STUB1
- SDCCAG7
- HSPABP2
- CHIP
- NY-CO-7
纯化方法 ProBond Resin chromatography UniProt编号 - Q9UNE7
UniProt汇总 FUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
SIZE: 303 amino acids; 34856 Da
SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.
SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain.产品使用声明 质量保证 Routinely evaluated by ubiquitin assay 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 2 years at -70°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 50 µg
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