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merck millipore,默克密理博,AB3314P,Anti-Monocarboxylate Transporter 4 Antibody
产品名称：Anti-Monocarboxylate Transporter 4 Antibody
产品型号：AB3314P
Detect Monocarboxylate Transporter 4 using this Anti-Monocarboxylate Transporter 4 Antibody validated for use in ELISA & WB.
merck millipore,默克密理博,AB3314P,Anti-Monocarboxylate Transporter 4 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3314P Replaces AB3546P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Monocarboxylate Transporter 4 Antibody Alternate Names - MCT4
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA and 0.05% sodium azide. 应用 应用 Detect Monocarboxylate Transporter 4 using this Anti-Monocarboxylate Transporter 4 Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-5 mg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 19 amino acid peptide sequence near the C-terminus of rat/human/mouse MCT4. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes rat Monocarboxylate Transporter 4 (MCT4/MOT4/ SLC16A3). The immunogen shows no significant sequence homology with other MCT. MCT4 is prominently expressed in skeletal muscle and other cells with high glycolytic rate such as tumors cells and white blood cells suggesting an important role in lactic acid efflux.
Note: According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Consult Halestrap and Price (1999) Biochem. J. 343:281-299.
SPECIES REACTIVITIES:
Rat. The immunogen sequence is 100% conserved in human and mouse and 78% conserved in chicken. Reactivity with other species has not been confirmed.品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004207.2
- NM_001042422.1
- NM_001042423.1
Entrez基因汇总 Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM] 基因符号 - MCT4
- SLC16A3
- MCT3
- MGC138472
- MGC138474
UniProt编号 - O15427
UniProt汇总 FUNCTION: SwissProt: O15427 # Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
SIZE: 465 amino acids; 49469 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle.
SIMILARITY: SwissProt: O15427 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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