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merck millipore,默克密理博,164603,3-Nitropropionic acid - CAS 504-88-1 - Calbiochem
产品名称：3-Nitropropionic acid - CAS 504-88-1 - Calbiochem
产品型号：164603
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.
merck millipore,默克密理博,164603,3-Nitropropionic acid - CAS 504-88-1 - Calbiochem
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重要规格表
经验配方 CAS号 C₃H₅NO₄ 504-88-1 描述 概述 A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. 产品目录编号 164603 品牌系列 Calbiochem®
同义词 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA 参考 参考 Beal, M., et al. 1993, J. Neurosci. 13, 4181.
Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.产品信息 CAS号 504-88-1 形式 Light yellow powder Hill配方 C₃H₅NO₄ 化学配方 C₃H₅NO₄ Molar Mass 119.1 结构配方图像 生物信息 纯度 ≥98% by NMR 理化信息 溶解度 DMSO or EtOH 安全信息 R相 R: 25-36/37/38
Toxic if swallowed.
Irritating to eyes, respiratory system and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Toxic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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