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品种反应性 主要应用 宿主 格式 抗体类型 R, H, Ht, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-471 Replaces 04-445 品牌系列 Upstate
商名 - Upstate
描述 Anti-Daxx Antibody 产品信息 格式 Serum 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-Daxx Antibody is an antibody against Daxx for use in IP, WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to residues 472-740 of human Daxx. 宿主 Rabbit 特异性 Daxx 同种型 IgG 品种反应性 RatHumanHamsterMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001350
基因符号 - DAP6
- DAXX
- MGC126246
- Daxx
- BING2
- hDaxx
- MGC126245
- EAP1
纯化方法 Antiserum UniProt编号 - Q9UER7
UniProt汇总 FUNCTION: SwissProt: Q9UER7 # Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
SIZE: 740 amino acids; 81373 Da
SUBUNIT: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By similarity). The non-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress.TISSUE SPECIFICITY: Ubiquitous.
PTM: Sumoylated. & Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by HIPK1 upon glucose deprivation. & Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation.
SIMILARITY: SwissProt: Q9UER7 ## Belongs to the DAXX family.产品使用声明 质量保证 routinely evaluated by immunoblot in HeLa nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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