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merck millipore,默克密理博,324630,EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem
产品名称：EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem
产品型号：324630
The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.
merck millipore,默克密理博,324630,EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₂₃N₅O · HCl 51350-19-7 描述 概述 The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC 50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC 50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities. 产品目录编号 324630 品牌系列 Calbiochem®
同义词 erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl 参考 参考 Burton, P., et al. 2010. Biochem. J. in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.产品信息 CAS号 51350-19-7 具有ATP竞争性 N 形式 White solid Hill配方 C₁₄H₂₃N₅O · HCl 化学配方 C₁₄H₂₃N₅O · HCl Molar Mass 313.8 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 PDE 2 主靶IC50 0.8 and 2 µM against human and procine PDE II, respectively 主靶Ki 4 nM against adenosine deaminase 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
上一件merck millipore产品：merck millipore,默克密理博,539185,Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MAB2170,Anti-Huntingtin Protein Antibody, a.a. 1247-1646, clone HU-4E6
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