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merck millipore,默克密理博,539185,Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem
产品名称：Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem
产品型号：539185
The Proteasome Inhibitor XX, GL5, also referenced under CAS 146304-91-8, controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applica More>>
merck millipore,默克密理博,539185,Proteasome Inhibitor XX, GL5 - CAS 146304-91-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₈H₇NO₂S₃ 146304-91-8 描述 概述 A cell-permeable thienyl-oxathiazolone compound that effectively kills non-replicating Mycobacterium tuberculosis (~320- or 12,600-fold drop in BCG titre over 4 days by 50 µM GL5 with or without 50 µM DETA-NO, respectively) by selectively inhibiting its proteasome activity (by ~90% over 4 hours with 50 µM GL5) in a substrate-competitive and irreversible manner, while exhibiting little activity against trypsin, cathepsin B, MMP-2, or human 20S proteasome β1/2/5. GL5 displays no antibacterial activity against M. avium-intracellulare, Staphylococcus aureus, Salmonella enterica var. Typhimurium, or Pseudomonas aeruginosa. Although GL5 is known to reversibly inhibit α-chymotrypsin (Ki = 0.064 µM), it exerts no apparent toxicity to human or monkey cells. GL5 is reasonably stable in RPMI medium (t1/2 = 110 mins at 37°C) albeit its moderate chemical reactivity toward glutathione (12.7% over 30 min at pH 7.0, RT; 10 µM GL5 and 25 µM GSH). 产品目录编号 539185 品牌系列 Calbiochem®
同义词 5-(5-Methyl-2-(methylthio)thiophen-3-yl)-1,3,4-oxathiazol-2-one 参考 参考 Lin. G., et al. 2009. Nature 461, 621. 产品信息 CAS号 146304-91-8 形式 Brown solid Hill配方 C₈H₇NO₂S₃ 化学配方 C₈H₇NO₂S₃ Molar Mass 245.3 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,324630,EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem
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