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  • merck millipore,默克密理博,AB3245,Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody

  • merck millipore,默克密理博,AB3245,Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody

    产品名称：Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody
    产品型号：AB3245
    Use Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody (Rabbit Polyclonal Antibody) validated in IP, WB to detect Topoisomerase (DNA) II Binding Protein 1 also known as TopBP1. Less<<

    merck millipore,默克密理博,AB3245,Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3245,Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3245
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody
    Alternate Names
    • TopBP1
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate, pH 7-8 containing 0.1% sodium azide.
    应用
    应用 Use Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody (Rabbit Polyclonal Antibody) validated in IP, WB to detect Topoisomerase (DNA) II Binding Protein 1 also known as TopBP1.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000-1:10,000

    Immunoprecipitation: 0.5 to 2.5 μL

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to a portion of human TopBP1 encoded within exon 29.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Topoisomerase (DNA) II Binding Protein 1 (TopBP1).

    SPECIES REACTIVITIES:

    Other species have not been tested.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_007027.2
    Entrez基因汇总 This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
    基因符号
    • KIAA0259
    • TOPBP1
    • TOP2BP1
    • TopBP1
    UniProt编号
    • Q92547
    UniProt汇总 FUNCTION: SwissProt: Q92547 # Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
    SIZE: 1522 amino acids; 170679 Da
    SUBUNIT: Binds EDD, E2F1, PML, RAD9A, SMARCA2, SMARCA4 and POLE. May interact with TOP2B.
    SUBCELLULAR LOCATION: Nucleus. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation.
    TISSUE SPECIFICITY: Highly expressed in heart, brain, placenta, lung and kidney.
    PTM: Phosphorylated on serine and threonine residues in response to X-ray irradiation. & Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.
    SIMILARITY: SwissProt: Q92547 ## Contains 8 BRCT domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted for up to 6 months after date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3245,Anti-Topoisomerase (DNA) II Binding Protein 1 Antibody

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