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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB13437 Replaces MAB1338 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-TIMP-1 Antibody, clone 8E8.2 Alternate Names - Tissue Inhibitor of Metalloproteinase-1
产品信息 格式 Purified 演示 Liquid at 1 mg/mL containing 0.1% sodium azide. 应用 应用 Anti-TIMP-1 Antibody, clone 8E8.2 detects level of TIMP-1 & has been published & validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot. When used against the reduced protein, identifies bands at 29 kDa. Suggested working dilutions: 1:1000 for colorimetric (BCIP/NBT) detection; 1:5,000 for chemiluminescent substrates. ELISA Optimal working dilutions must be determined by end user. 生物信息 免疫原品种 Synthetic peptide based on the carboxy terminal region of the human sequence 克隆 8E8.2 宿主 Mouse 特异性 MAB13437 is directed against a synthetic peptide based on the carboxy terminal region of the human sequence. It does not cross-react with other TIMP family members (TIMP-2, TIMP-3, TIMP-4, etc.). TIMP-1 levels in quiescent cells and tissues is low (pg/ml), and stimulation with the phorbol ester TPA or protein concentration is often needed to visualize protein bands. In addition, cell types differ greatly in the amount of TIMP-1 produced. 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003254.2
Entrez基因汇总 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. 基因符号 - HCI
- TIMP1
- TIMP
- FLJ90373
- CLGI
- EPA
- EPO
- TIMP-1
UniProt编号 - P01033
UniProt汇总 FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
SIZE: 207 amino acids; 23171 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The undiluted antibody solution is stable for approximately 6 months when stored 2-8°C. 包装信息 数量 100 µg
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